Article
A two-codon mutant of cholera toxin lacking ADP-ribosylating activity functions as an effective adjuvant for eliciting mucosal and systemic cellular immune responses to peptide antigens.
Vaccine - 9 Dec 2004
Lomada Dakshayani, Gambhira Ratish, Nehete Pramod N, Guhad Faisal A, Chopra Ashok K, Peterson Johnny W, Sastry K Jagannadha
Abstract excerpt
Vaccination with peptide antigens is an effective strategy against mucosal viral infections. We tested a two-codon mutant of cholera toxin (CT-2*) lacking ADP-ribosylating activity and toxicity as a mucosal adjuvant for T cell epitope peptides for intranasal immunization of mice. Efficient induct...
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