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Article

Developmental arrest and ecdysteroid deficiency resulting from mutations at the dre4 locus of Drosophila.

Genetics - 1 Mar 1992

Sliter T J, Gilbert L I

Abstract excerpt

Loss-of-function mutations of the dre4 gene of Drosophila melanogaster caused stage-specific developmental arrest, the stages of arrest coinciding with periods of ecdysteroid (molting hormone) regulated development. Nonconditional mutations resulted in the arrest of larval development in the first instar; embryogenesis was not impaired, and mutant larvae were behaviorally normal and long-lived. At 31 degrees the...

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Identifiers

PMID: 1551577
DOI: 10.1093/genetics/130.3.555
PMCID: PMC1204873

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