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Article

Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency.

Development (Cambridge, England) - 1 Jan 2002

Park Yoonseong, Filippov Valery, Gill Sarjeet S, Adams Michael E

Abstract excerpt

At the end of each developmental stage, insects perform a stereotypic behavioral sequence leading to ecdysis of the old cuticle. While ecdysis-triggering hormone (ETH) is sufficient to trigger this sequence, it has remained unclear whether it is required. We show that deletion of eth, the gene encoding ETH in Drosophila, leads to lethal behavioral and physiological deficits. Null mutants (eth(-)) fail to inflate...

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PMID: 11807040
DOI: 10.1242/dev.129.2.493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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