Article
Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays.
BMC genomics - 28 Oct 2004
Adjaye James, Herwig Ralf, Herrmann Doris, Wruck Wasco, Benkahla Alia, Brink Thore C, Nowak Monika, Carnwath Joseph W, Hultschig Claus, Niemann Heiner, Lehrach Hans
Abstract excerpt
BACKGROUND: Cross-species gene-expression comparison is a powerful tool for the discovery of evolutionarily conserved mechanisms and pathways of expression control. The usefulness of cDNA microarrays in this context is that broad areas of homology are compared and hybridization probes are sufficiently large that small inter-species differences in nucleotide sequence would not affect the analytical results. This...
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