Article
Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population.
Genomics - 1 Nov 2004
Gómez Mariluz, Clark Rhonda M, Nath Swapan K, Bhatti Saeeda, Sharma Rajesh, Alonso Elisa, Rasmussen Astrid, Bidichandani Sanjay I
Abstract excerpt
Friedreich ataxia accounts for approximately 75% of European recessive ataxia patients. Approximately 98% of pathogenic chromosomes have large expansions of a GAA triplet repeat in the FRDA gene (E alleles), and strong linkage disequilibrium among polymorphisms spanning the FRDA locus indicates a common origin for all European E alleles. In contrast, we found that only 14 of 151 (9.3%) Mexican Mestizo patients...
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