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Article

VP1 of Foot-and-Mouth Disease Virus Induces Apoptosis via the Akt Signaling Pathway

6 Oct 2004

Abstract excerpt

Foot-and-mouth disease virus (FMDV) binds to cellular integrins through an RGD motif in its capsid protein, VP1. It is unclear, however, what kind of cellular event(s) are triggered after the binding of VP1 to the cells. In this study, we show that aqueous soluble recombinant DNA-derived VP1 (rVP1) of FMDV induced apoptosis of BHK-21 cells after binding to integrins. In addition, treatment of BHK-21 cells with...

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PMID: 15466859
DOI: 10.1074/jbc.m403686200

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