Exhaustive screening of exon 10 CFTR gene mutations and polymorphisms by denaturing gradient gel electrophoresis: applications to genetic counselling in cystic fibrosis.

doi:10.1016/0890-8508(92)90068-9

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Article

Exhaustive screening of exon 10 CFTR gene mutations and polymorphisms by denaturing gradient gel electrophoresis: applications to genetic counselling in cystic fibrosis.

Molecular and cellular probes - 1 Feb 1992

Ghanem N, Fanen P, Martin J, Conteville P, Yahia-Cherif Z, Vidaud M, Goossens M

Abstract excerpt

Several mutations in the cystic fibrosis (CF) gene have been reported. Ten, including the most prevalent mutation in Caucasians, delta F508, are located in exon 10 of the gene, in addition to five sequence polymorphisms. We have previously presented a strategy based on denaturing gradient gel ana...

Topics

Base Sequence
Cystic Fibrosis
Exons
Genetic Counseling
Humans
Molecular Sequence Data
Mutation
Polymorphism, Genetic

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