Article
Prenatal diagnosis of cystic fibrosis in different European populations: application of denaturing gradient gel electrophoresis.
Fetal diagnosis and therapy - 1 Jan 2000
Férec C, Verlingue C, Audrézet M P, Guillermit H, Quéré I, Raguenes O, Mercier B
Abstract excerpt
The cystic fibrosis transmembrane regulator gene, one of the most commonly mutated in the European population, was cloned in 1989 and since then has been extensively analysed in patients of various ethnic backgrounds. We have screened the entire coding sequences of the cystic fibrosis transmembra...
Topics
- Chorionic Villi Sampling
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- Electrophoresis, Polyacrylamide Gel
- Europe
- Female
- France
- Humans
- Membrane Proteins
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Pregnancy
- Prenatal Diagnosis
- Risk Factors
- Sequence Analysis, DNA
- Urea