Article
Intraspecies variability in the dose-response relationship for Salmonella Enteritidis associated with genetic differences in cellular immune response.
Journal of food protection - 1 Sept 2004
Havelaar Arie, Garssen Johan, Takumi Katsuhisa, Koedam Marjan, Ritmeester Wilma, de la Fonteyne Lisette, Bousema Teun, Vos Joseph
Abstract excerpt
To evaluate the effects of differences in host cellular immunity, we studied the dose-response relationship for infection with Salmonella enterica serovar Enteritidis (SE) in two different rat strains, skewed towards T helper 1 (Th1, Lewis rats) or T helper 2 (Th2, Brown Norway rats) immunoregulation. Rats were exposed orally to different doses of SE after overnight starvation and neutralization of gastric acid....
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