Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group.

doi:10.1046/j.1526-4610.1997.3708479.x

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Article

Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group.

Headache - 1 Sept 1997

Ophoff R A, Terwindt G M, Vergouwe M N, Frants R R, Ferrari M D

Abstract excerpt

A gene for familial hemiplegic migraine, a subtype of migraine with aura, was assigned to chromosome 19p13. In this region, we identified a brain-specific P/Q-type calcium-channel alpha 1A-subunit gene, CACNA 1A, with 47 exons covering 300 kb. Sequencing of all exons and their flanking surroundin...

Topics

Alleles
Animals
Calcium Channels
Chromosomes, Human, Pair 19
Hemiplegia
Humans
Migraine Disorders
Mutation

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