Article
Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA microarray.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2004
Bianchi Fabrizio, Hu Jiangting, Pelosi Giuseppe, Cirincione Rosalia, Ferguson Mary, Ratcliffe Cathy, Di Fiore Pier Paolo, Gatter Kevin, Pezzella Francesco, Pastorino Ugo
Abstract excerpt
PURPOSE: Spiral computed tomography (CT) can detect lung cancer at an early stage, but the malignant potential is unknown. The question is, as follows: do these small lesions have the same lethal potential as do symptomatic tumors? EXPERIMENTAL DESIGN: We used a cDNA microarray platform and compared the gene expression profile of spiral CT-detected lung carcinomas with a matched case-control population of...
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