Article
A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role for UBE3A.
American journal of medical genetics. Part A - 15 Nov 2004
Jiang Yong-Hui, Sahoo Trilochan, Michaelis Ron C, Bercovich Dani, Bressler Jan, Kashork Catherine D, Liu Qian, Shaffer Lisa G, Schroer Richard J, Stockton David W, Spielman Richard S, Stevenson Roger E, Beaudet Arthur L
Abstract excerpt
The genetic contribution to autism is often attributed to the combined effects of many loci (ten or more). This conclusion is based in part on the much lower concordance for dizygotic (DZ) than for monozygotic (MZ) twins, and is consistent with the failure to find strong evidence for linkage in genome-wide studies. We propose that the twin data are compatible with oligogenic inheritance combined with a major,...
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