Article
Total cell‐free DNA (β‐globin gene) distribution in maternal plasma at the second trimester: a new prospective for preeclampsia screening
1 Sept 2004
Abstract excerpt
OBJECTIVES: Levels of cell-free foetal DNA (f-DNA) in maternal plasma are higher in those asymptomatic subjects who will eventually develop preeclampsia. f-DNA is, however, informative only for those women bearing a male foetus, by amplification of Y-specific sequences and represents a small fraction of total circulating DNA that can be dosed by using ubiquitous genes as well as beta-globin. In this study, we...
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