Article
Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma.
The Journal of investigative dermatology - 1 Oct 2004
Arbiser Jack L, Fan Chun-Yang, Su Xiaobo, Van Emburgh Beth O, Cerimele Francesca, Miller Mark Steven, Harvell Jeff, Marinkovich M Peter
Abstract excerpt
Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive disorder characterized by the loss of collagen type VII, an intrinsic component of the anchoring fibrils, which attach the epidermis to the dermis. Of the genetic blistering disorders, RDEB has the highest rate of morbidity and mortality, with morbidity arising from fusion of digits in a mitten-glove deformity and growth retardation...
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