Article
Myofiber adaptational response to exercise in a mouse model of nemaline myopathy.
Muscle & nerve - 1 Oct 2004
Nair-Shalliker Visalini, Kee Anthony J, Joya Josephine E, Lucas Christina A, Hoh Joseph F, Hardeman Edna C
Abstract excerpt
In some muscle diseases, such as muscular dystrophy, exercise can increase muscle damage and alter myofiber adaptation. We determined whether this is also true for the congenital muscle disease nemaline myopathy using our mouse model of this disease. Nemaline mice expressing a mutant alpha-tropomyosinslow protein [alpha-Tmslow(Met9Arg)] in skeletal muscle underwent 4 weeks of treadmill exercise. Exercise...
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