Article
XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease.
Cancer - 15 Sept 2004
Mertens Ann C, Mitby Pauline A, Radloff Gretchen, Jones Irene M, Perentesis John, Kiffmeyer William R, Neglia Joseph P, Meadows Anna, Potter John D, Friedman Debra, Yasui Yutaka, Robison Leslie L, Davies Stella M
Abstract excerpt
BACKGROUND: One of the most serious late effects of treatment for childhood cancer is the occurrence of subsequent malignancy. Survivors of Hodgkin disease (HD), in particular, have been shown to be at high risk of subsequent malignancy, the occurrence of which has been associated strongly with exposure to radiotherapy. METHODS: In the current study, the authors investigated the association between polymorphisms...
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