[Enhance effect of Ox-LDL on NF-kappaB activity in glomerular mesangial cells from the Zucker rats].

Abstract excerpt

AIM: To study the effect of oxidized low-density lipoprotein (Ox-LDL) on nuclear NF-kappaB activity in cultured glomerular mesangial cells (GMCs) from the Zucker rats and the correlation between the change of NF-kappaB activity and ras's age and genotype. METHODS: Four groups of GMCs (O(3m),O(10m), L(3m) and L(10m)) from the 3- and 10- month (fa/fa) and 3- and 10- month lean (Fa/Fa) Zucker rats were stimulated...

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