Article
Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder.
Neuropsychobiology - 1 Jan 2004
Tsai Shih-Jen, Hong Chen-Jee, Yu Younger W-Y, Chen Tai-Jui, Wang Ying-Chieh, Lin Wen-Kuo
Abstract excerpt
Serotonin 1B receptors (5-HT1B) are autoreceptors involved in the local inhibitory control of serotonin release, and have been suggested to play a role in the pathogenesis of major depressive disorder (MDD) and the antidepressant effects of the selective serotonin reuptake inhibitors in patients. We genotyped the 5-HT1B A-161T polymorphism in 160 patients with MDD and 160 normal controls. We then tested the...
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