Article
Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice.
Circulation - 21 Sept 2004
Dawson Dana, Lygate Craig A, Saunders James, Schneider Jürgen E, Ye Xujiong, Hulbert Karen, Noble J Alison, Neubauer Stefan
Abstract excerpt
BACKGROUND: Insufficient techniques exist for rapid and reliable phenotype characterization of genetically manipulated mouse models of cardiac dysfunction. We developed a new, robust, 3-dimensional echocardiography (3D-echo) technique and hypothesized that this 3D-echo technique is as accurate as magnetic resonance imaging (MRI) and histology for assessment of left ventricular (LV) volume, ejection fraction,...
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