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Article

Mechanism for transcriptional synergy between interferon regulatory factor (IRF)‐3 and IRF‐7 in activation of the interferon‐β gene promoter

24 Aug 2004

Abstract excerpt

The interferon-beta promoter has been studied extensively as a model system for combinatorial transcriptional regulation. In virus-infected cells the transcription factors ATF-2, c-Jun, interferon regulatory factor (IRF)-3, IRF-7 and NF-kappaB, and the coactivators p300/CBP play critical roles in the activation of this and other promoters. It remains unclear, however, why most other combinations of AP-1, IRF and...

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Identifiers

PMID: 15355347
DOI: 10.1111/j.1432-1033.2004.04310.x

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