Article
In a Vietnamese population, MSX1 variants contribute to cleft lip and palate.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000
Suzuki Yasushi, Jezewski Peter A, Machida Junichiro, Watanabe Yoriko, Shi Min, Cooper Margaret E, Viet Le Thi, Nguyen Thi Duc Tin, Hai Huynh, Natsume Nagato, Shimozato Kazuo, Marazita Mary L, Murray Jeffrey C
Abstract excerpt
PURPOSE: To identify causes of nonsyndromic cleft lip and palate in a Vietnamese population. METHODS: In this study, 175 families with at least one case of cleft lip and/or palate were studied using the candidate genes TGFA, MSX1, and TGFB3. RESULTS: Transmission distortion for alleles of MSX1 were demonstrated for the whole population and two missense mutations were identified, including one (P147Q) that is...
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