Immunomagnetic removal of neurons from developing chick optic tectum results in glial phenotypic instability.

Abstract excerpt

The ability of embryonic day 12 and 13 optic tectum cells to replace depleted A2B5(+) cells and neurons was tested by immunomagnetic cell separation. Nearly all purified surface A2B5(-) cells were identified as glia by immunoreactivity for either glutamine synthetase of galactocerebroside. Most (approximately 80%) of the purified A2B5(-) cells became A2B5(+) after 1 day in culture, although no increase in the...

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