Article
The effect of tissue type plasminogen activator (tPA) on osteoclastic resorption in embryonic mouse long bone explants: a possible role for the growth factor domain of tPA.
Bone and mineral - 1 Apr 1992
Hoekman K, Löwik C W, van de Ruit M, Bijvoet O L, Verheijen J H, Papapoulos S E
Abstract excerpt
Osteoblasts produce proteolytic enzymes and their production is regulated by osteotropic agents. It has been suggested that these proteases play a role in bone resorption by removing the superficial collagenous layer from the bone matrix and indirectly inducing migration of osteoclast precursors...
Topics
- Amino Acid Chloromethyl Ketones
- Analysis of Variance
- Animals
- Bone Resorption
- Calcium
- Culture Techniques
- Female
- Fibrinolysin
- Mice
- Mutation
- Osteoclasts
- Pregnancy
- Recombinant Proteins
- Tissue Plasminogen Activator
- Transforming Growth Factor alpha