Article
Preeclampsia and its interaction with common variants in thrombophilia genes.
Journal of thrombosis and haemostasis : JTH - 1 Sept 2004
De Maat M P M, Jansen M W J C, Hille E T M, Vos H L, Bloemenkamp K W M, Buitendijk S, Helmerhorst F M, Wladimiroff J W, Bertina R M, De Groot C J M
Abstract excerpt
Recently, it has been proposed that abnormalities in coagulation and fibrinolysis contribute to the development of preeclampsia by increasing the thrombotic tendency. This hypothesis was tested in women who have had preeclampsia (cases) compared with matched controls. Polymorphisms in the thrombophilia genes [plasminogen activator inhibitor type 1 [PAI-1 -675(4G/5G)], thrombin activatable fibrinolysis inhibitor...
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