Article
Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia.
Gynecologic and obstetric investigation - 1 Jan 2003
Fabbro Dora, D'Elia Angela V, Spizzo Riccardo, Driul Lorenza, Barillari Giovanni, Di Loreto Carla, Marchesoni Diego, Damante Giuseppe
Abstract excerpt
It is known that the plasminogen activator inhibitor 1 (PAI-1) protein levels are increased in placentas of preeclamptic subjects. Therefore, we assessed whether polymorphisms related to the transcriptional control of the PAI-1 gene (-675 4G/5G and -844G/A) are associated with mild preeclampsia. We compared 52 women with preeclampsia to 80 women with a normal pregnancy. None of the preeclamptic women suffered...
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