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Article

Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS.

Brain research - 17 Sept 2004

Groeneveld G J, Van Muiswinkel F L, Sturkenboom J M, Wokke J H J, Bär P R, Van den Berg L H

Abstract excerpt

The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariectomy on female G93A mSOD1 transgenic mice, and the effect of subsequent treatment with...

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Identifiers

PMID: 15328040
DOI: 10.1016/j.brainres.2004.06.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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