Article
Peripheral blood neutrophils in chronically neutropenic patients respond to granulocyte-macrophage colony-stimulating factor with a specific increase in CR1 expression and CR1 transcription.
Blood - 1 Apr 1992
Moore F D, Jack R M, Antin J H
Abstract excerpt
Chronically neutropenic patients from a phase I/II protocol were studied for neutrophil (PMN) abnormalities related to therapeutic use of granulocyte-macrophage colony-stimulating factor (GM-CSF). We analyzed phenotype by flow cytometry to measure indirect immunofluorescent staining and activatio...
Topics
- Antigens, Surface
- Flow Cytometry
- Fluorescent Antibody Technique
- Gene Expression
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Leukocyte Count
- Neutropenia
- Neutrophils
- Nucleic Acid Hybridization
- Phenotype
- RNA, Messenger
- Receptors, Complement
- Receptors, Complement 3b
- Recombinant Proteins
- Transcription, Genetic