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Article

Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping.

Genomics - 1 Feb 1992

Nickerson D A, Whitehurst C, Boysen C, Charmley P, Kaiser R, Hood L

Abstract excerpt

Using a combination of denaturing gradient gel electrophoresis and direct DNA sequencing, we have found that multiple (4 to 7) biallelic sequence polymorphisms can be located within short DNA segments, 300 to 2400 bp. Here, we report on the identification of three clusters of DNA polymorphisms, one in each of the constant regions of the human T cell receptor alpha and beta gene complexes on human chromosomes 14...

Topics

Alleles
Base Sequence
Chromosome Mapping
DNA
DNA Probes
Genetic Linkage
Genetic Markers
Humans
Linkage Disequilibrium
Molecular Sequence Data
Multigene Family

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Polymorphism, Genetic

RNA, Transfer, Thr

Receptors, Antigen, T-Cell, alpha-beta

Sequence Tagged Sites

Source

Identifiers

PMID: 1531472
DOI: 10.1016/0888-7543(92)90388-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1531472-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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