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Article

Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis.

The American journal of gastroenterology - 1 Aug 2004

Gelrud Andres, Sheth Sunil, Banerjee Subhas, Weed Deborah, Shea Julie, Chuttani Ram, Howell Douglas A, Telford Jennifer J, Carr-Locke David L, Regan Meredith M, Ellis Lynda, Durie Peter R, Freedman Steven D

Abstract excerpt

BACKGROUND: The mechanism by which pancreas divisum may lead to recurrent episodes of acute pancreatitis in a subset of individuals is unknown. Abnormalities of the cystic fibrosis gene product (CFTR) have been implicated in the genesis of idiopathic chronic pancreatitis. The aim of this study was to determine if CFTR function is abnormal in patients with pancreas divisum and recurrent acute pancreatitis...

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Source

Identifiers

PMID: 15307877
DOI: 10.1111/j.1572-0241.2004.30834.x

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis.PMID 15307877Read ↗

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Reduced CFTR function and the pathobiology of idiopathic pancreatitis.Semantic proximity Read ↗

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Risk of pancreatitis with mutation of the cystic fibrosis gene.Semantic proximity Read ↗

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Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations.Semantic proximity Read ↗

The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis.Semantic proximity Read ↗

Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis.Semantic proximity Read ↗

Pancreas divisum is not a cause of pancreatitis by itself but acts as a partner of genetic mutations.Semantic proximity Read ↗

A patient with pancreas divisum, recurrent acute pancreatitis, and homozygosity for the cystic fibrosis transmembrane regulator-associated protein 5T allele.Semantic proximity Read ↗

CFTR function is impaired in a subset of patients with pancreatitis carrying rare CFTR variants.Semantic proximity Read ↗

Pancreatitis and cystic fibrosis gene mutations.Semantic proximity Read ↗

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