Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On the origins of mitosis and why it is involved in cancer.

Medical hypotheses - 1 Jun 1992

Cotton D W, Cross S S

Abstract excerpt

It is suggested that mitosis arose in evolution as a mechanism for 'excreting' damaged DNA (mutations). The mechanism for excretion involved replication of the DNA and was thus a pre-adaptation that could be used for cell replication. In multicellular organisms the mutated cells cannot always be lost and may persist as neoplasms.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cell Division
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Mitosis

Share to Models, Biological

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 1528155
DOI: 10.1016/0306-9877(92)90083-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

On the origins of mitosis and why it is involved in cancer.PMID 1528155Read ↗

Cancer morphology, carcinogenesis and genetic instability: a background.Semantic proximity Read ↗

The role of proliferation in the origin of mutations in mammalian cells.Semantic proximity Read ↗

Reappraisal of the Hansemann–Boveri hypothesis on the origin of tumorsSemantic proximity Read ↗

Mitosis is not the only distributor of mutated cells: non-mitotic endopolyploid cells produce reproductive genome-reduced cells.Semantic proximity Read ↗

A thermodynamic interpretation of malignancy: do the genes come later?Semantic proximity Read ↗

[Oncogenes and mitotic regulators: a change in perspective of our view of neoplastic processes].Semantic proximity Read ↗

Mitosis without DNA replication in mammalian somatic cellsSemantic proximity Read ↗

Pathways for maintenance of telomeres and common fragile sites during DNA replication stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.