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Article

Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells.

Stem cells (Dayton, Ohio) - 1 Jan 2004

Urbach Achiya, Schuldiner Maya, Benvenisty Nissim

Abstract excerpt

Human embryonic stem (ES) cells are pluripotent cells derived from blastocyst-stage embryos. It has been suggested that these cells should play a major role in transplantation medicine and be able to advance our knowledge in human embryology. We propose that these cells should also play a vital role in the creation of models of human disorders. This aspect would be most valuable where animal models failed to...

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Source

Identifiers

PMID: 15277709
DOI: 10.1634/stemcells.22-4-635

Genes

HPRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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