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Article

A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary.

Biology of reproduction - 1 Jan 2002

Cheng Guojun, Weihua Zhang, Mäkinen Sirpa, Mäkelä Sari, Saji Shigehira, Warner Margaret, Gustafsson Jan-Ake, Hovatta Outi

Abstract excerpt

Estrogen receptor beta (ERbeta) is highly expressed, but ERalpha is not detectable in granulosa cells in the mouse ovary. In ERbeta knockout (BERKO) mice, there is abnormal follicular development and very reduced fertility. At 3 wk of age, no significant morphologic differences were discernable between wild type (WT) and BERKO mouse ovaries, but by 5 mo of age, atretic follicles were abundant in BERKO mice and...

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Identifiers

PMID: 11751267
DOI: 10.1095/biolreprod66.1.77

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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