Article
Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.
The Journal of biological chemistry - 24 Sept 2004
Sakai Takashi, Liu Li, Teng Xichuan, Mukai-Sakai Rika, Shimada Hidenori, Kaji Ryuji, Mitani Tasuku, Matsumoto Mitsuru, Toida Kazunori, Ishimura Kazunori, Shishido Yuji, Mak Tak W, Fukui Kiyoshi
Abstract excerpt
Nucling is a novel protein isolated from murine embryonal carcinoma cells with an up-regulated expression during cardiac muscle differentiation. We show here that Nucling was up-regulated by proapoptotic stimuli and important for the induction of apoptosis after cytotoxic stress. We further demonstrated that overexpressed Nucling was able to induce apoptosis. In Nucling-deficient cells, the expression levels of...
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