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Article

Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK.

The Journal of biological chemistry - 10 Sept 2004

Gensch Erin, Gallup Marianne, Sucher Anatol, Li Daizong, Gebremichael Assefa, Lemjabbar Hassan, Mengistab Aklilu, Dasari Vijay, Hotchkiss Jon, Harkema Jack, Basbaum Carol

Abstract excerpt

In smokers' lungs, excessive mucus clogs small airways, impairing respiration and promoting recurrent infection. A breakthrough in understanding this pathology was the realization that smoke could directly stimulate mucin synthesis in lung epithelial cells and that this phenomenon was dependent on the cell surface receptor for epidermal growth factor, EGFR. Distal steps in the smoke-triggered pathway have not yet...

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Source

Identifiers

PMID: 15262961
DOI: 10.1074/jbc.M406866200

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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