Article
IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs.
Bioinformatics (Oxford, England) - 4 Aug 2004
Yousfi Monod Mehdi, Giudicelli Véronique, Chaume Denys, Lefranc Marie-Paule
Abstract excerpt
MOTIVATION: To create the enormous diversity of 10(12) immunoglobulins (IG) and T cell receptors (TR) per individual, very complex mechanisms occur at the DNA level: the combinatorial diversity results from the junction of the variable (V), diversity (D) and joining (J) genes; the N-diversity represents the addition at random of nucleotides not encoded in the genome; and somatic hypermutations occur in IG...
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