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Article

Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency.

The Journal of biological chemistry - 1 Oct 2004

Behr Rüdiger, Brestelli John, Fulmer James T, Miyawaki Nobuyuki, Kleyman Thomas R, Kaestner Klaus H

Abstract excerpt

Foxa1 is a member of the winged helix family of transcription factors and is expressed in the collecting ducts of the kidney. We investigated its potential contribution to renal physiology in Foxa1-deficient mice on a defined genetic background. Foxa1(-/-) mice are dehydrated and exhibit electrolyte imbalance as evidenced by elevated hematocrit and plasma urea levels, hypernatremia, and hyperkalemia. This...

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Source

Identifiers

PMID: 15252040
DOI: 10.1074/jbc.M403354200

Genes

BSND
CASR
CLCNKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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