Article
Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.
Blood - 15 Oct 2004
Novak Anne J, Grote Deanna M, Stenson Mary, Ziesmer Steven C, Witzig Thomas E, Habermann Thomas M, Harder Brandon, Ristow Kay M, Bram Richard J, Jelinek Diane F, Gross Jane A, Ansell Stephen M
Abstract excerpt
BLyS, recently shown to be critical for survival of normal B cells, has been found to be elevated in a number of immune disease models. A role for BLyS in the survival of malignant B cells has also been revealed and we therefore sought to identify a role for BLyS and its receptors in non-Hodgkin lymphoma (NHL). We found that tumor cells from all NHL histologic subtypes expressed one or more of 3 known receptors...
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