Article
Functional consequences of mutation of highly conserved serine residues, found at equivalent positions in the N- and C-terminal domains of mammalian hexokinases.
Archives of biochemistry and biophysics - 1 Oct 1992
Baijal M, Wilson J E
Abstract excerpt
Despite the extensive sequence similarity between the N- and C-terminal halves of the 100-kDa molecular weight mammalian hexokinases (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1), reflecting their evolutionary origin by duplication and fusion of a gene coding for a smaller ancestral hexokinase,...
Topics
- Animals
- Base Sequence
- Glucose-6-Phosphate
- Glucosephosphates
- Hexokinase
- Mitochondria
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligodeoxyribonucleotides
- Precipitin Tests
- Recombinant Proteins
- Serine
- Structure-Activity Relationship
- Transfection