Article
Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome.
The Journal of infectious diseases - 1 Aug 2004
Ng Margaret H L, Lau Kin-Mang, Li Libby, Cheng Suk-Hang, Chan Wing Y, Hui Pak K, Zee Benny, Leung Chi-Bon, Sung Joseph J Y
Abstract excerpt
Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P=.00008...
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