Article
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.
Nature - 8 Jul 2004
Li K S, Guan Y, Wang J, Smith G J D, Xu K M, Duan L, Rahardjo A P, Puthavathana P, Buranathai C, Nguyen T D, Estoepangestie A T S, Chaisingh A, Auewarakul P, Long H T, Hanh N T H, Webby R J, Poon L L M, Chen H, Shortridge K F, Yuen K Y, Webster R G, Peiris J S M
Abstract excerpt
A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2-4) and...
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