Article
GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone.
The Journal of clinical endocrinology and metabolism - 1 Jul 2004
Meysing Astrid U, Kanasaki Haruhiko, Bedecarrats Gregoy Y, Acierno James S, Conn P Michael, Martin Kathryn A, Seminara Stephanie B, Hall Janet E, Crowley William F, Kaiser Ursula B
Abstract excerpt
Mutations in the GnRH receptor gene (GNRHR) are a cause of idiopathic hypogonadotropic hypogonadism. We describe a normosmic female subject with congenital idiopathic hypogonadotropic hypogonadism in whom treatment with pulsatile GnRH resulted in an unusual response. The subject not only required an increased dose of pulsatile GnRH for ovarian follicular development, but LH secretion did not increase...
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