Article
Integrated genomic and proteomic analyses of gene expression in Mammalian cells.
Molecular & cellular proteomics : MCP - 1 Oct 2004
Tian Qiang, Stepaniants Serguei B, Mao Mao, Weng Lee, Feetham Megan C, Doyle Michelle J, Yi Eugene C, Dai Hongyue, Thorsson Vesteinn, Eng Jimmy, Goodlett David, Berger Joel P, Gunter Bert, Linseley Peter S, Stoughton Roland B, Aebersold Ruedi, Collins Steven J, Hanlon William A, Hood Leroy E
Abstract excerpt
Using DNA microarrays together with quantitative proteomic techniques (ICAT reagents, two-dimensional DIGE, and MS), we evaluated the correlation of mRNA and protein levels in two hematopoietic cell lines representing distinct stages of myeloid differentiation, as well as in the livers of mice treated for different periods of time with three different peroxisome proliferative activated receptor agonists. We...
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