Article
Mono-nucleotide repeats (MNRs): a neglected polymorphism for generating high density genetic maps in silico.
Human genetics - 1 Aug 2004
Cohen Helit, Danin-Poleg Yael, Cohen Cyril J, Sprecher Eli, Darvasi Ariel, Kashi Yechezkel
Abstract excerpt
Short, tandemly repeated DNA motifs, termed SSRs (simple sequence repeats) are widely distributed throughout eukaryotic genomes and exhibit a high degree of polymorphism. The availability of size-based methods for genotyping SSRs has made them the markers of choice for genetic linkage studies in all higher eukaryotes. These genotyping methods are not efficiently applicable to mononucleotide repeats (MNRs)....
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