Article
The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus.
Journal of human genetics - 1 Jan 2004
Kamimura Junichi, Wakui Keiko, Kadowaki Hiroko, Watanabe Yukio, Miyake Kazuaki, Harada Naoki, Sakamoto Michiyo, Kinoshita Akira, Yoshiura Koh-Ichiro, Ohta Tohru, Kishino Tatsuya, Ishikawa Mutsuo, Kasuga Masato, Fukushima Yoshimitsu, Niikawa Norio, Matsumoto Naomichi
Abstract excerpt
Type 2 diabetes mellitus (T2DM) is a group of multifactorial disorders due to either defective insulin secretion or action. Despite the fact that numerous genetic researches of T2DM have been pursued, the pathogenic mechanisms remain obscure. We encountered a T2DM family associated with a balanced reciprocal translocation, t(3;9)(p21.31;q33.1). To isolate a candidate gene susceptible to T2DM, we constructed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.