Article
Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia.
Dementia and geriatric cognitive disorders - 1 Jan 2004
Emanuele Enzo, Peros Emmanouil, Tomaino Carmine, Feudatari Enrica, Bernardi Livia, Binetti Giuliano, Maletta Raffaele, Micieli Giuseppe, Bruni Amalia C, Geroldi Diego
Abstract excerpt
Lipoprotein(a) [Lp(a)] level is a newly established vascular risk factor which has been suggested to play a role in dementia. However, the majority of Lp(a) cell-to-cell interactions are mediated by its specific apolipoprotein(a) [apo(a)] moiety. This suggests that the size polymorphism of apo(a) may be of importance in conveying the Lp(a)-related risk. Specifically, we postulated that variation in apo(a) isoform...
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