Article
Mapping the assembly pathway of Bluetongue virus scaffolding protein VP3.
Virology - 1 Jul 2004
Kar Alak Kanti, Ghosh Mrinal, Roy Polly
Abstract excerpt
The structure of the Bluetongue virus (BTV) core and its outer layer VP7 has been solved by X-ray crystallography, but the assembly intermediates that lead to the inner scaffolding VP3 layer have not been defined. In this report, we addressed two key questions: (a) the role of VP3 amino terminus in core assembly and its interaction with the transcription complex (TC) components; and (b) the assembly intermediates...
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