Article
Interleukin-1β and tumour necrosis factor-α promote the transformation of human immortalised mesothelial cells by erionite
1 Jul 2004
Abstract excerpt
Asbestos fails to induce the transformation of human mesothelial cells in vitro although it has been known as a potential carcinogen to human mesothelial cells. Interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) are major cytokines released by macrophages after inhalation of asbestos. These cytokines can regulate mesothelial cell proliferation both in vitro and in vivo. In the present...