Article
Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes.
Oncology reports - 1 Jul 2004
Mimori Koshi, Ueo Hiroaki, Kuroki Tamotsu, Shiraishi Takeshi, Creer Shenoa, Taylor Scott, Ishii Hideshi, Mori Masaki
Abstract excerpt
We confirmed that the enzyme activity of thymidine phosphorylase (TP) can substitute for 5'-deoxy-5-fluorouridine (5'-dFUR) sensitivity in clinical colorectal cancer (CRC) tissues. Moreover, the idenfication of susceptible genes other than TP will be desired for prediction or treatment of 5'-dFUR. We initially established conditions for the MTT assay system in vivo to compare the growth inhibition rate and TP...
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