Article
The role of molecular genetics in the pathogenesis and diagnosis of neonatal sepsis.
Clinics in perinatology - 1 Mar 2004
Del Vecchio Antonio, Laforgia Nicola, Capasso Mario, Iolascon Achille, Latini Giuseppe
Abstract excerpt
Polymorphisms within genes encoding endogenous mediators of inflammation are good candidates for the individual differences in systemic inflammatory responses of neonates to infection. Ina similar manner, polymorphisms in the genes encoding drug metabolizing enzymes, drug transporters, and drug receptors can influence a neonate's risk of an adverse drug reaction or can alter the efficacy of drug treatment....
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