Article
Frontotemporal dementia linked to chromosome 3.
Dementia and geriatric cognitive disorders - 1 Jan 2004
Brown Jerry, Gydesen Susanne, Johannsen Peter, Gade Anders, Skibinski Gaia, Chakrabarti Lisa, Brun Arne, Spillantini Maria, Yancopoulou Despina, Thusgaard Tove, Sorensen Asger, Fisher Elizabeth, Collinge John
Abstract excerpt
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
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